The -2518 A/G MCP-1 polymorphism as a risk factor of inflammatory bowel disease.
نویسندگان
چکیده
UNLABELLED Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances. The AIM OF THE STUDY was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development. MATERIAL AND METHODS Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn's disease) as well as 210 healthy controls. RESULTS The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn's disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively). CONCLUSIONS Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.
منابع مشابه
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ورودعنوان ژورنال:
- Polski przeglad chirurgiczny
دوره 84 5 شماره
صفحات -
تاریخ انتشار 2012